Drug resistance in amoebiasis.

نویسندگان

  • Devendra Bansal
  • Nancy Malla
  • R C Mahajan
چکیده

Amoebiasis caused by Entamoeba histolytica, is a major public health problem in developing countries. Morphologically similar E. dispar is non pathogenic. Because of the redefinition of E. histolytica and E. dispar, and the limited number of antiamoebic drugs available, a new approach to treat such individuals is necessary. The cost of treating asymptomatic individuals is highly exorbitant and not justifiable. The indiscriminate use of antiamoebic drugs can result in increased minimum inhibitory concentration (MIC) values against Entamoeba species, and treatment failure may emerge as an important public health problem. Development of new antiamoebic drugs is still in infancy and vaccine development appears to be distant dream. In future, the development of drug resistance may seriously affect the control of disease. This review discusses the factors involved in drug resistance mechanisms developed by the parasite.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Multidrug resistance in amoebiasis patients.

BACKGROUND & OBJECTIVES Amoebiasis, caused by Entamoeba sp. a protozoan parasite, is a major public health problem in tropical and subtropical countries. The symptomatic patients are treated by specific chemotherapy. However, there are reports of treatment failure in some cases suggesting the possibility of drug resistance. The present study was therefore planned to assess the presence and expr...

متن کامل

Resistance of C57BL/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production.

Resistance to intestinal amoebiasis is mouse strain dependent. C57BL/6 (B6) mice clear Entamoeba histolytica within hours of challenge, whereas C3H and CBA strains are susceptible to infection and disease. In this study, we show using bone marrow (BM) chimeric mice that mouse strain-dependent resistance is mediated by nonhemopoietic cells; specifically, B6 BM --> CBA recipients remained suscept...

متن کامل

Standardisation of Kutajadi Vishesh Yoga

Amoebiasis is a problem in northern India. In Ayurveda several herbal drugs are mentioned, to be used for controlling the amatisara (amoebiasis) but none of the drug are found having potent effect to iradicate the disease. In ancient literature kutaj (Holarrhena antidysentrica) is mentioned in commonest was for controlling the disease this plant is prevalently found in Himalayan and vindhaya ar...

متن کامل

Clinical Studies on Amoebiasis and Giardiasis Evaluating the Efficacy of Kutaja (holarrhena Antidysenterica) in Entamoeba Histolytica Cyst Passers

The clinical study records the clinical presentations of forty cases with amoebias and / or giardiasis including the efficacy of Kutaja (Holarrhena antidysenterica) in intestinal amoebiasis. E. H. Cyst passers also have symptoms like loose motions, constipation, flatulence, abdominal cramping, diminished appetite and mucus in stools. Patients with giardiasis have more tendency to diarrhoea and ...

متن کامل

New developments in the therapy of amoebiasis.

Progress report New developments in the therapy of amoebiasis Although frequently overlooked in practice, it has long been taught that for the adequate therapy of invasive amoebiasis treatment should be directed at all the sites where Entamoeba histolytica may be present. Hence the ideal amoebicide should be active within the bowel lumen, in the bowel wall, and systemically, particularly in the...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Indian journal of medical research

دوره 123 2  شماره 

صفحات  -

تاریخ انتشار 2006